2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138711
    Benzyl-PEG8-Ots 1144113-17-6
    Benzyl-PEG8-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Benzyl-PEG8-Ots
  • HY-140604
    Azido-PEG3-Sulfone-PEG4-Boc 2055023-76-0
    Azido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-Sulfone-PEG4-Boc
  • HY-141194
    N-Boc-PEG16-alcohol 2592432-32-9
    N-Boc-PEG16-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-PEG16-alcohol
  • HY-138312
    m-PEG1000-CH2COOH
    m-PEG1000-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG1000-CH2COOH
  • HY-140490
    Cbz-N-PEG10-acid
    Cbz-N-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-N-PEG10-acid
  • HY-140034
    Propargyl-PEG12-amine 2264091-73-6
    Propargyl-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG12-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG12-amine
  • HY-121957
    BnO-PEG1-CH2COOH 93206-09-8
    BnO-PEG1-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    BnO-PEG1-CH2COOH
  • HY-176186
    4-Hydroxy-1-piperidinepropanamide 1056123-56-8
    4-Hydroxy-1-piperidinepropanamide is a PROTAC linker that can be used in the synthesis of PROTAC DDR1 degrader-1 (HY-176184).
    4-Hydroxy-1-piperidinepropanamide
  • HY-140092
    N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) 2112737-60-5
    N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl)
  • HY-141078
    N-(m-PEG4)-N'-(azide-PEG4)-Cy7 2107273-40-3
    N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(m-PEG4)-N'-(azide-PEG4)-Cy7
  • HY-140835
    Boc-N-Amido-PEG3-azide 642091-68-7
    Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-N-Amido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-N-Amido-PEG3-azide
  • HY-140515
    NH-bis(PEG3-acid) 1814901-04-6
    NH-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG3-acid)
  • HY-128802
    Tos-PEG3-O-C1-CH3COO 855120-17-1
    Tos-PEG3-O-C1-CH3COO (PROTAC Linker 6) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Tos-PEG3-O-C1-CH3COO
  • HY-D1295
    Pyrene azide 3 2252168-06-0
    Pyrene azide 3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Pyrene azide 3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Pyrene azide 3
  • HY-140259
    N-(Boc-PEG4)-NH-PEG4-NH-Boc 2112737-17-2
    N-(Boc-PEG4)-NH-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Boc-PEG4)-NH-PEG4-NH-Boc
  • HY-140032
    Alkyne-ethyl-PEG1-Boc 2100306-55-4
    Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Alkyne-ethyl-PEG1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-ethyl-PEG1-Boc
  • HY-132119
    Boc-NHCH2CH2-PEG1-azide 176220-30-7
    Boc-NHCH2CH2-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NHCH2CH2-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NHCH2CH2-PEG1-azide
  • HY-138755
    S-acetyl-PEG4-NHBoc 1404111-70-1
    S-acetyl-PEG4-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    S-acetyl-PEG4-NHBoc
  • HY-140439
    Boc-Aminooxy-PEG3-thiol 1895922-75-4
    Boc-Aminooxy-PEG3-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminooxy-PEG3-thiol
  • HY-132051
    Benzyl-PEG14-alcohol
    Benzyl-PEG14-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG14-alcohol
PROTAC Linkers Isoform Comparison

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